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Journal of Virology, July 2002, p. 6841-6844, Vol. 76, No. 13
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.13.6841-6844.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans

Carmen P. Alvarez,1 Fátima Lasala,1 Jaime Carrillo,1,{dagger} Oscar Muñiz,2 Angel L. Corbí,2 and Rafael Delgado1*

Laboratory of Molecular Microbiology, Hospital 12 de Octubre,1 Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain2

Received 4 January 2002/ Accepted 29 March 2002

Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.

* Corresponding author. Mailing address: Laboratory of Molecular Microbiology, Department of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain. Phone: 34 91 3908428. Fax: 34 91 5652765. E-mail: rdelgado{at}hdoc.insalud.es.

{dagger} Present address: Instituto de Investigaciones Biomédicas, Universidad Autónoma de Madrid, Madrid, Spain.

Journal of Virology, July 2002, p. 6841-6844, Vol. 76, No. 13
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.13.6841-6844.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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