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Journal of Virology, July 2002, p. 6636-6642, Vol. 76, No. 13
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.13.6636-6642.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Targeting and Hematopoietic Suppression of Human CD34+ Cells by Measles Virus{dagger}

Marianne Manchester,1,2* Kent A. Smith,3 Danelle S. Eto,1,2 Hugh B. Perkin,3 and Bruce E. Torbett3

Departments of Cell Biology,1 Molecular and Experimental Medicine,3 Center for Integrative Molecular Biosciences, The Scripps Research Institute, La Jolla, California 920372

Received 9 January 2002/ Accepted 26 March 2002

The major cause of mortality in measles is generalized suppression of cell-mediated immunity that persists following virus clearance and results in secondary infections. The mechanisms contributing to this long-term immunosuppression are not clear. Herein we present evidence that measles virus (MV) disrupts hematopoiesis by infecting human CD34+ cells and human bone marrow stroma. MV infection does not affect the hematopoietic capability of hematopoietic stem cells (HSCs) directly; rather, the infection impairs the ability of stroma to support development of HSCs. These results suggest that MV-mediated defects in hematopoiesis contribute to the long-term immunosuppression seen in measles.

* Corresponding author. Mailing address: Department of Cell Biology, Mail Code CB248, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (858) 784-8086. Fax: (858) 784-2139. E-mail: marim{at}scripps.edu.

{dagger} This is manuscript number 13548-NP from The Scripps Research Institute.

Journal of Virology, July 2002, p. 6636-6642, Vol. 76, No. 13
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.13.6636-6642.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Copyright © 2002 by the American Society for Microbiology. All rights reserved.