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Journal of Virology, June 2002, p. 6408-6412, Vol. 76, No. 12
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.12.6408-6412.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Pre- and Postexposure Prophylaxis of Ebola Virus Infection in an Animal Model by Passive Transfer of a Neutralizing Human Antibody

Paul W. H. I. Parren,1,{dagger} Tom W. Geisbert,2 Toshiaki Maruyama,1,{ddagger} Peter B. Jahrling,2* and Dennis R. Burton1*

Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037,1 U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 217022

Received 12 October 2001/ Accepted 8 March 2002

A neutralizing human monoclonal antibody, KZ52, protects guinea pigs from lethal Ebola Zaire virus challenge. Administration before or up to 1 h after challenge resulted in dose-dependent protection by the antibody. Interestingly, some antibody-treated animals survived despite developing high-level viremia, suggesting that the mechanism of protection by KZ52 may extend beyond reduction of viremia by virus neutralization. KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection.

* Corresponding author: Mailing address for Dennis R. Burton: Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037. Phone: (858) 784-9298. Fax: (858) 784-8360. E-mail: burton{at}scripps.edu. Mailing address for Peter B. Jahrling: Headquarters, USAMRIID, Ft. Detrick, Frederick, MD 21702. Phone: (301) 619-2772. Fax: (301) 619-4625. E-mail: Peter.Jahrling{at}DET.AMEDD.ARMY.MIL.

{dagger} Present address: Genmab, Utrecht, The Netherlands.

{ddagger} Present address: Alexion Antibody Technologies, San Diego, CA 92121.

Journal of Virology, June 2002, p. 6408-6412, Vol. 76, No. 12
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.12.6408-6412.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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