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Journal of Virology, June 2002, p. 6376-6381, Vol. 76, No. 12
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.12.6376-6381.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Prior Vaccination Increases the Epitopic Breadth of the Cytotoxic T-Lymphocyte Response That Evolves in Rhesus Monkeys following a Simian-Human Immunodeficiency Virus Infection

Sampa Santra,1 Dan H. Barouch,1 Marcelo J. Kuroda,1 Jörn E. Schmitz,1 Georgia R. Krivulka,1 Kristin Beaudry,1 Carol I. Lord,1 Michelle A. Lifton,1 Linda S. Wyatt,2 Bernard Moss,2 Vanessa M. Hirsch,3 and Norman L. Letvin1*

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215,1 Laboratory of Molecular Microbiology,2 Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208523

Received 10 December 2001/ Accepted 8 March 2002

Although recent evidence has confirmed the importance of cytotoxic T-lymphocyte (CTL) responses in controlling human immunodeficiency virus type 1 and simian immunodeficiency virus replication, the relevance of the epitopic breadth of those CTL responses remains unexplored. In the present study, we sought to determine whether vaccination can expand CTL populations which recognize a repertoire of viral epitopes that is greater than is typically generated in the course of a viral infection. We demonstrate that potent secondary CTL responses to subdominant epitopes are rapidly generated following a pathogenic simian-human immunodeficiency virus challenge of rhesus monkeys vaccinated with plasmid DNA or recombinant modified vaccinia virus Ankara vaccines. These data indicate that prior vaccination can increase the breadth of the CTL response that evolves after an AIDS virus infection.

* Corresponding author. Mailing address: Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, P.O. Box 15732, Boston, MA 02215. Phone: (617) 667-2766. Fax: (617) 667-8210. E-mail: nletvin{at}caregroup.harvard.edu.

Journal of Virology, June 2002, p. 6376-6381, Vol. 76, No. 12
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.12.6376-6381.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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