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Journal of Virology, June 2002, p. 6364-6369, Vol. 76, No. 12
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.12.6364-6369.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Minute Virus of Mice Small Nonstructural Protein NS2 Interacts and Colocalizes with the Smn Protein

Philip J. Young,1 Klaus T. Jensen,2 Lisa R. Burger,2 David J. Pintel,2 and Christian L. Lorson1*

Department of Biology, Arizona State University, Tempe, Arizona 85287,1 Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri 652122

Received 11 January 2002/ Accepted 18 March 2002

The small nonstructural protein NS2 of the minute virus of mice (MVM) is required for efficient viral replication, although its mode of action is unclear. Here we demonstrate that NS2 and survival motor neuron protein (Smn) interact in vitro and in vivo. NS2 and Smn also colocalize in infected nuclei at late times following MVM infection.

* Corresponding author. Mailing address: Department of Biology, Arizona State University, Tempe, AZ 85287. Phone: (480) 965-5444. Fax: (480) 965-2519. E-mail: clorson{at}asu.edu.

Journal of Virology, June 2002, p. 6364-6369, Vol. 76, No. 12
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.12.6364-6369.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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