This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Knauss, D. J. Articles by Young, J. A. T. Search for Related Content PubMed PubMed Citation Articles by Knauss, D. J. Articles by Young, J. A. T.

 Previous Article  |  Next Article 

Journal of Virology, June 2002, p. 5404-5410, Vol. 76, No. 11
0022-538X/02/$04.00+0     DOI: 10.1128/JVI.76.11.5404-5410.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Fifteen-Amino-Acid TVB Peptide Serves as a Minimal Soluble Receptor for Subgroup B Avian Leukosis and Sarcoma Viruses

McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin—Madison, Madison, Wisconsin 53706

Received 9 November 2001/ Accepted 20 February 2002

The TVB receptor for subgroup B, D, and E avian sarcoma and leukosis viruses (ASLVs) is a tumor necrosis factor receptor-related protein that is most closely related to the TRAIL receptors. Here we show that the major subgroup B viral interaction determinants of TVB are contained within a linear 15-amino-acid peptide derived from the N-terminal region of the receptor. Moreover, this peptide was sufficient not only for binding to ASLV-B but also for activating viral entry into mammalian cells that lacked the cognate viral receptor. Peptide-dependent viral entry was blocked in the presence of bafilomycin A1, indicating that virions can be trafficked to an acidic endosomal fusion compartment without the need for physical attachment of the viral receptor to a cellular membrane.

This article has been cited by other articles:

• Reinisova, M., Senigl, F., Yin, X., Plachy, J., Geryk, J., Elleder, D., Svoboda, J., Federspiel, M. J., Hejnar, J. (2008). A Single-Amino-Acid Substitution in the TvbS1 Receptor Results in Decreased Susceptibility to Infection by Avian Sarcoma and Leukosis Virus Subgroups B and D and Resistance to Infection by Subgroup E In Vitro and In Vivo. J. Virol. 82: 2097-2105 [Abstract] [Full Text]  
• Zhang, B., Sun, C., Jin, S., Cascio, M., Montelaro, R. C. (2008). Mapping of Equine Lentivirus Receptor 1 Residues Critical for Equine Infectious Anemia Virus Envelope Binding. J. Virol. 82: 1204-1213 [Abstract] [Full Text]  
• Tiwari, V., O'Donnell, C., Copeland, R. J., Scarlett, T., Liu, J., Shukla, D. (2007). Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells. J. Gen. Virol. 88: 1075-1079 [Abstract] [Full Text]  
• Kwon, H., Bai, Q., Baek, H.-J., Felmet, K., Burton, E. A., Goins, W. F., Cohen, J. B., Glorioso, J. C. (2006). Soluble V Domain of Nectin-1/HveC Enables Entry of Herpes Simplex Virus Type 1 (HSV-1) into HSV-Resistant Cells by Binding to Viral Glycoprotein D. J. Virol. 80: 138-148 [Abstract] [Full Text]  
• Klucking, S., Collins, A. S., Young, J. A. T. (2005). Avian Sarcoma and Leukosis Virus Cytopathic Effect in the Absence of TVB Death Domain Signaling. J. Virol. 79: 8243-8248 [Abstract] [Full Text]  
• Vigdorovich, V., Strong, R. K., Miller, A. D. (2005). Expression and Characterization of a Soluble, Active Form of the Jaagsiekte Sheep Retrovirus Receptor, Hyal2. J. Virol. 79: 79-86 [Abstract] [Full Text]  
• Melikyan, G. B., Barnard, R. J. O., Markosyan, R. M., Young, J. A. T., Cohen, F. S. (2004). Low pH Is Required for Avian Sarcoma and Leukosis Virus Env-Induced Hemifusion and Fusion Pore Formation but Not for Pore Growth. J. Virol. 78: 3753-3762 [Abstract] [Full Text]  
• Smith, J. G., Mothes, W., Blacklow, S. C., Cunningham, J. M. (2004). The Mature Avian Leukosis Virus Subgroup A Envelope Glycoprotein Is Metastable, and Refolding Induced by the Synergistic Effects of Receptor Binding and Low pH Is Coupled to Infection. J. Virol. 78: 1403-1410 [Abstract] [Full Text]  
• Miura, H. S., Nakagaki, K., Taguchi, F. (2004). N-Terminal Domain of the Murine Coronavirus Receptor CEACAM1 Is Responsible for Fusogenic Activation and Conformational Changes of the Spike Protein. J. Virol. 78: 216-223 [Abstract] [Full Text]  
• Ohno, S., Seki, F., Ono, N., Yanagi, Y. (2003). Histidine at position 61 and its adjacent amino acid residues are critical for the ability of SLAM (CD150) to act as a cellular receptor for measles virus. J. Gen. Virol. 84: 2381-2388 [Abstract] [Full Text]  
• Narayan, S., Barnard, R. J. O., Young, J. A. T. (2003). Two Retroviral Entry Pathways Distinguished by Lipid Raft Association of the Viral Receptor and Differences in Viral Infectivity. J. Virol. 77: 1977-1983 [Abstract] [Full Text]  
• Diaz-Griffero, F., Hoschander, S. A., Brojatsch, J. (2002). Endocytosis Is a Critical Step in Entry of Subgroup B Avian Leukosis Viruses. J. Virol. 76: 12866-12876 [Abstract] [Full Text]