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Journal of Virology, January 2002, p. 427-431, Vol. 76, No. 1
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.1.427-431.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Interleukin-1{alpha} Released from Epithelial Cells after Adenovirus Type 37 Infection Activates Intercellular Adhesion Molecule 1 Expression on Human Vascular Endothelial Cells

Cheng-Hsien Chang,1,2 Yan Huang,1 Andrew C. Issekutz,1,3,4 May Griffith,5 Kuei-Hsiang Lin,6 and Robert Anderson1*

Departments of Microbiology & Immunology,1 Pathology,3 Pediatrics Dalhousie University, Halifax B3H 4H7, Nova Scotia,4 University of Ottawa Eye Institute, Ottawa Hospital-General Campus, Ottawa, Ontario K1H 8L6, Canada,5 Department of Ophthalmology,2 Clinical Laboratory Kaohsiung Medical University, Kaohsiung, Taiwan6

Received 2 August 2001/ Accepted 5 October 2001

A key event in virus-induced inflammation (leukocyte extravasation through the endothelium) is the local activation of endothelial cells, as indicated by the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. In order to identify triggers of inflammation in adenovirus infection, we inoculated respiratory and ocular epithelial cells with adenovirus type 37 (Ad37), a human pathogen associated with keratoconjunctivitis as well as urogenital and respiratory infections. Fluids from virus-infected epithelial cells activated ICAM-1 (and to a lesser extent, VCAM-1) expression on cultured human umbilical vein endothelial cells. Blocking studies with anticytokine antibodies implicated interleukin-1{alpha} (IL-1{alpha}) as the epithelial cell-derived factor which activated endothelial cell ICAM-1 expression. The results thus identify epithelial cell-derived IL-1{alpha} as a potentially important activator of endothelial cells in Ad37-induced inflammation.

* Corresponding author. Mailing address: Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. Phone: (902) 494-1063. Fax: (902) 494-5125. E-mail: robert.anderson{at}dal.ca.

Journal of Virology, January 2002, p. 427-431, Vol. 76, No. 1
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.1.427-431.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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