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Journal of Virology, January 2002, p. 416-420, Vol. 76, No. 1
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.1.416-420.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Calcineurin-Dependent Mitochondrial Disturbances in Calcium-Induced Apoptosis of Human Immunodeficiency Virus gp160-Expressing CD4+ Cells

Masafumi Sasaki,1,2 Kozo Miyazaki,3 Yasuhiro Koga,4 Genki Kimura,1 Kikuo Nomoto,3 and Hiroki Yoshida3*

Department of Virology,1 Technical Support Laboratory,2 Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582,3 Department of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan4

Received 8 June 2001/ Accepted 24 September 2001

In CD4+ UE160 cells with inducible expression of gp160, mechanisms of apoptosis induced by human immunodeficiency virus (HIV) Env protein were analyzed. Induction of gp160 caused intracellular calcium increase followed by the release of cytochrome c from mitochondria, which was inhibited by calcineurin inhibitors. Association of BAD with Bcl-xL was observed, and a portion of BAD was dephosphorylated after induction of gp160. These data suggested that calcineurin plays a role in the HIV Env-induced apoptosis in a mitochondrion-dependent way.

* Corresponding author. Mailing address: Department of Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Phone: 81-92-642-6823. Fax: 81-92-642-6825. E-mail: hyoshida{at}bioreg.kyushu-u.ac.jp.

Journal of Virology, January 2002, p. 416-420, Vol. 76, No. 1
0022-538X/01/$04.00+0     DOI: 10.1128/JVI.76.1.416-420.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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