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Journal of Virology, May 2001, p. 4448-4452, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4448-4452.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Macaques with Rapid Disease Progression and Simian Immunodeficiency Virus Encephalitis Have a Unique Cytokine Profile in Peripheral Lymphoid Tissues

Marlene S. Orandle, Kenneth C. Williams,dagger Andrew G. MacLean, Susan V. Westmoreland, and Andrew A. Lackner*

Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772

Received 20 October 2000/Accepted 24 January 2001

The influence of host cytokine response on viral load, disease progression, and neurologic lesions was investigated in the simian immunodeficiency virus (SIV)-infected macaque model of AIDS. Cytokine gene expression (interleukin-1beta [IL-1beta ], IL-2, IL-6, IL-10, gamma interferon [IFN-gamma ], and tumor necrosis factor alpha [TNF-alpha ]) and viral loads were evaluated by semiquantitative reverse transcription-PCR in lymph nodes of 5 control animals and 28 animals infected with SIVmac251 at the terminal stages of AIDS. Infected animals showed higher expression of IFN-gamma , IL-6, and IL-10 mRNAs compared with controls. Levels of all cytokines were comparable between animals with rapid (survival, <200 days) or slow/normal (survival, >200 days) disease progression. However, among rapid progressors, the eight animals with SIV encephalitis had a unique cytokine profile (increased IL-2, IL-6, and IFN-gamma ) that was associated with higher viral loads. These observations provide evidence that host cytokine responses may influence SIV neuropathogenesis independent of disease progression.

* Corresponding author. Mailing address: New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Dr., P.O. Box 9102, Southborough, MA 01772-9102. Phone: (508) 624-8018. Fax: (508) 624-8181. E-mail: andrew_lackner{at}hms.harvard.edu.

dagger Present address: Beth Israel Deaconess Medical Center, Boston, MA 02215.

Journal of Virology, May 2001, p. 4448-4452, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4448-4452.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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