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Journal of Virology, May 2001, p. 4413-4419, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4413-4419.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Restoration of Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Responses in CD8+ T Cells from Late-Stage Patients on Prolonged Antiretroviral Therapy by Stimulation In Vitro with HIV-1 Protein-Loaded Dendritic Cells

Zheng Fan,1 Xiao-Li Huang,1 Luann Borowski,1 John W. Mellors,1,2,3,4 and Charles R. Rinaldo Jr.1,3,*

Department of Infectious Diseases and Microbiology, Graduate School of Public Health,1 and Departments of Medicine2 and Pathology,3 School of Medicine, University of Pittsburgh, and Veterans Affairs Medical Center,4 Pittsburgh, Pennsylvania 15261

Received 7 July 2000/Accepted 28 January 2001

We demonstrate that dendritic cells loaded in vitro with human immunodeficiency virus type 1 (HIV-1) protein-liposome complexes activate HLA class I-restricted anti-HIV-1 cytotoxic T-lymphocyte and gamma interferon (IFN-gamma ) responses in autologous CD8+ T cells from late-stage HIV-1-infected patients on prolonged combination drug therapy. Interleukin-12 enhanced this effect through an interleukin-2- and IFN-gamma -mediated pathway. This suggests that dendritic cells from HIV-1-infected persons can be engineered to evoke stronger anti-HIV-1 CD8+ T-cell reactivity as a strategy to augment antiretroviral therapy.

* Corresponding author: Mailing address: A427 Crabtree Hall, University of Pittsburgh Graduate School of Public Health, 130 DeSoto St., Pittsburgh, PA 15261. Phone: (412) 624-3928. Fax: (412) 624-4953. E-mail: rinaldo{at}pitt.edu.

Journal of Virology, May 2001, p. 4413-4419, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4413-4419.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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