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Journal of Virology, May 2001, p. 4394-4398, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4394-4398.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vivo Accumulation of Cyclin A and Cellular Replication Factors in Autonomous Parvovirus Minute Virus of Mice-Associated Replication Bodies

Tarig Bashir, Jean Rommelaere, and Celina Cziepluch*

Applied Tumor Virology Unit F0100 and Institut National de la Santé et de la Recherche Médicale U 375, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

Received 14 December 2000/Accepted 6 February 2001

Autonomous parvovirus minute virus of mice (MVM) DNA replication is strictly dependent on cellular factors expressed during the S phase of the cell cycle. Here we report that MVM DNA replication proceeds in specific nuclear structures termed autonomous parvovirus-associated replication bodies, where components of the basic cellular replication machinery accumulate. The presence of DNA polymerases alpha  and delta  in these bodies suggests that MVM utilizes partially preformed cellular replication complexes for its replication. The recruitment of cyclin A points to a role for this cell cycle factor in MVM DNA replication beyond its involvement in activating the conversion of virion single-stranded DNA to the duplex replicative form.

* Corresponding author. Mailing address: Applied Tumor Virology, Abteilung F0100 and INSERM U 375, Deutsches Krebsforschungszentrum, Postfach 101949, 69009 Heidelberg, Germany. Phone: 49 6221 424977. Fax: 49 6221 424962. E-mail: C.Cziepluch{at}dkfz-heidelberg.de.

Journal of Virology, May 2001, p. 4394-4398, Vol. 75, No. 9
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.9.4394-4398.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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