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Journal of Virology, April 2001, p. 3965-3970, Vol. 75, No. 8
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.8.3965-3970.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Propagation of Rat Parvovirus in Thymic Lymphoma Cell Line C58(NT)D and Subsequent Appearance of a Resistant Cell Clone after Lytic Infection

Yutaka Ueno, Tanenobu Harada, Hiroyoshi Iseki, Takayuki Ohshima, Fumihiro Sugiyama, and Ken-ichi Yagami*

Institute of Basic Medical Sciences and Laboratory Animal Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan

Received 21 September 2000/Accepted 17 January 2001

Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphocytotropic infection. We found that RPV was propagated in rat thymic lymphoma cell line C58(NT)D and induced apoptosis. Interestingly, a resistant subclone, C58(NT)D/R, from surviving cells after lytic infection had differentiated phenotypic modifications, such as increased cell adherence, resistance to apoptosis, and suppressed tumorigenicity.

* Corresponding author. Mailing address: Laboratory Animal Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Phone: (81) 298-53-3386. Fax: (81) 298-53-3380. E-mail: kenyagam{at}sakura.cc.tsukuba.ac.jp.

Journal of Virology, April 2001, p. 3965-3970, Vol. 75, No. 8
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.8.3965-3970.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.