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Journal of Virology, April 2001, p. 3696-3705, Vol. 75, No. 8
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.8.3696-3705.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Reassortment In Vivo: Driving Force for Diversity of Human Rotavirus Strains Isolated in the United Kingdom between 1995 and 1999

Miren Iturriza-Gómara, Beverley Isherwood,dagger Ulrich Desselberger, and Jim Gray*

Clinical Microbiology and Public Health Laboratory, Addenbrooke's Hospital, Cambridge CB2 2QW, United Kingdom

Received 11 September 2000/Accepted 23 January 2001

The G and P genotypes of 3,601 rotavirus strains collected in the United Kingdom between 1995 and 1999 were determined (M. Iturriza-Gómara et al., J. Clin. Microbiol. 38:4394-4401, 2000). In 95.4% of the strains the most common G and P combinations, G1P[8], G2P[4], G3P[8], and G4P[8], were found. A small but significant number (2%) of isolates from the remaining strains were reassortants of the most common cocirculating strains, e.g., G1P[4] and G2P[8]. Rotavirus G9P[6] and G9P[8] strains, which constituted 2.7% of all viruses, were genetically closely related in their G components, but the P components of the G9P[8] strains were very closely related to those of cocirculating strains of the more common G types (G1, G3, and G4). In conclusion, genetic interaction by reassortment among cocirculating rotaviruses is not a rare event and contributes significantly to their overall diversity.

* Corresponding author. Mailing address: Clinical Microbiology and Public Health Laboratory, Level 6, Addenbrooke's Hospital, Hills Rd., Cambridge CB2 2QW, United Kingdom. Phone: 44-(0)1223-257028. Fax: 44-(0)1223-242775. E-mail: jg2{at}mole.bio.cam.ac.uk.

dagger Present address: Institute of Virology, University of Glasgow, Glasgow G11 5JR, United Kingdom.

Journal of Virology, April 2001, p. 3696-3705, Vol. 75, No. 8
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.8.3696-3705.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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