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Journal of Virology, April 2001, p. 3480-3482, Vol. 75, No. 7
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.7.3480-3482.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Regression of a Murine Gammaherpesvirus 68-Positive B-Cell Lymphoma Mediated by CD4 T Lymphocytes

Kevin A. Robertson, Edward J. Usherwood,dagger and Anthony A. Nash*

Department of Veterinary Pathology, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom

Received 27 October 2000/Accepted 5 January 2001

Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.

* Corresponding author. Mailing address: Department of Veterinary Pathology, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom. Phone: (44)131 650 6164. Fax: (44)131 650 6511. E-mail: Tony.Nash{at}ed.ac.uk.

dagger Present address: Trudeau Institute, Inc., Saranac Lake, NY 12983.

Journal of Virology, April 2001, p. 3480-3482, Vol. 75, No. 7
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.7.3480-3482.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.