This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Han, X.
Right arrow Articles by Cantin, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Han, X.
Right arrow Articles by Cantin, E.

 Previous Article  |  Next Article 

Journal of Virology, March 2001, p. 3048-3052, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.3048-3052.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Gender Influences Herpes Simplex Virus Type 1 Infection in Normal and Gamma Interferon-Mutant Mice

Xiao Han,1 Patric Lundberg,1 Becky Tanamachi,1,dagger Harry Openshaw,1,2 Jeff Longmate,3 and Edouard Cantin1,2,*

Departments of Virology1 and Neurology2 and Department of Biostatistics,3 City of Hope National Medical Center, Duarte, California 91010

Received 19 August 2000/Accepted 20 December 2000

Gender influences the incidence and severity of some bacterial and viral infections and autoimmune diseases in animal models and humans. To determine a gender-based difference, comparisons were made between male and female mice inoculated with herpes simplex virus type 1 (HSV-1) by the corneal route. Mortality was higher in the male mice of the three strains tested: 129/Sv//Ev wild type, gamma interferon (IFN-gamma ) knockout (GKO), and IFN-gamma receptor knockout (RGKO). Similarly, in vivo HSV-1 reactivation occurred more commonly in male mice, but the male-female difference in reactivation was restricted to the two knockout strains and was not seen in the 129/Sv//Ev control. Comparison among male mice of the three strains showed a higher mortality of the RGKO mice and a higher reactivation rate of the GKO and RGKO mice than of the 129/Sv//Ev males. In contrast, female RGKO and GKO mice did not differ from female 129/Sv//Ev controls in either mortality or reactivation. HSV-1 periocular and eyelid disease was also more severe in male and dihydrotestosterone (DHT)-treated female mice than in control female mice. These results show a consistent gender difference in HSV-1 infection, with a worse outcome in male mice. In addition, the results comparing GKO and RGKO mice to controls show differences only in male mice, suggesting that some effects of IFN-gamma , a key immunoregulatory molecule, are gender specific.

* Corresponding author. Mailing address: City of Hope Medical Center and Beckman Research Institute, Department of Virology, 1500 E. Duarte Rd., Duarte, CA 91010. Phone: (626) 301-8480. Fax: (626) 301-8852. E-mail: ecantin{at}coh.org.

dagger Present address: Harbor UCLA REI, Division of Medical Genetics, Torrance, CA 90502.

Journal of Virology, March 2001, p. 3048-3052, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.3048-3052.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Zhang, X., Castelli, F. A., Zhu, X., Wu, M., Maillere, B., BenMohamed, L. (2008). Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D. CVI 15: 1436-1449 [Abstract] [Full Text]  
  • Brown, A. S., Davis, J. M., Murphy, E. A., Carmichael, M. D., Carson, J. A., Ghaffar, A., Mayer, E. P. (2007). Susceptibility to HSV-1 infection and exercise stress in female mice: role of estrogen. J. Appl. Physiol. 103: 1592-1597 [Abstract] [Full Text]  
  • Dunn, S. E., Ousman, S. S., Sobel, R. A., Zuniga, L., Baranzini, S. E., Youssef, S., Crowell, A., Loh, J., Oksenberg, J., Steinman, L. (2007). Peroxisome proliferator-activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. JEM 204: 321-330 [Abstract] [Full Text]  
  • Jones, C., Inman, M., Peng, W., Henderson, G., Doster, A., Perng, G.-C., Angeletti, A. K. (2005). The Herpes Simplex Virus Type 1 Locus That Encodes the Latency-Associated Transcript Enhances the Frequency of Encephalitis in Male BALB/c Mice. J. Virol. 79: 14465-14469 [Abstract] [Full Text]  
  • Fuller, A. C., Kang, B., Kang, H. K., Yahikozowa, H., Dal Canto, M. C., Kim, B. S. (2005). Gender Bias in Theiler's Virus-Induced Demyelinating Disease Correlates with the Level of Antiviral Immune Responses. J. Immunol. 175: 3955-3963 [Abstract] [Full Text]  
  • Pasche, B., Kalaydjiev, S., Franz, T. J., Kremmer, E., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., Lengeling, A., Busch, D. H. (2005). Sex-Dependent Susceptibility to Listeria monocytogenes Infection Is Mediated by Differential Interleukin-10 Production. Infect. Immun. 73: 5952-5960 [Abstract] [Full Text]  
  • Burgos, J. S., Ramirez, C., Sastre, I., Alfaro, J. M., Valdivieso, F. (2005). Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender. J. Virol. 79: 1605-1612 [Abstract] [Full Text]  
  • Paharkova-Vatchkova, V., Maldonado, R., Kovats, S. (2004). Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors. J. Immunol. 172: 1426-1436 [Abstract] [Full Text]  
  • Mott, K. R., Osorio, N., Jin, L., Brick, D. J., Naito, J., Cooper, J., Henderson, G., Inman, M., Jones, C., Wechsler, S. L., Perng, G.-C. (2003). The bovine herpesvirus-1 LR ORF2 is critical for this gene's ability to restore the high wild-type reactivation phenotype to a herpes simplex virus-1 LAT null mutant. J. Gen. Virol. 84: 2975-2985 [Abstract] [Full Text]  
  • Lundberg, P., Welander, P., Openshaw, H., Nalbandian, C., Edwards, C., Moldawer, L., Cantin, E. (2003). A Locus on Mouse Chromosome 6 That Determines Resistance to Herpes Simplex Virus Also Influences Reactivation, While an Unlinked Locus Augments Resistance of Female Mice. J. Virol. 77: 11661-11673 [Abstract] [Full Text]  
  • Luker, G. D., Prior, J. L., Song, J., Pica, C. M., Leib, D. A. (2003). Bioluminescence Imaging Reveals Systemic Dissemination of Herpes Simplex Virus Type 1 in the Absence of Interferon Receptors. J. Virol. 77: 11082-11093 [Abstract] [Full Text]  
  • Lundberg, P., Welander, P., Han, X., Cantin, E. (2003). Herpes Simplex Virus Type 1 DNA Is Immunostimulatory In Vitro and In Vivo. J. Virol. 77: 11158-11169 [Abstract] [Full Text]  
  • Stanberry, L. R., Spruance, S. L., Cunningham, A. L., Bernstein, D. I., Mindel, A., Sacks, S., Tyring, S., Aoki, F. Y., Slaoui, M., Denis, M., Vandepapeliere, P., Dubin, G., the GlaxoSmithKline Herpes Vaccine Efficacy Study, (2002). Glycoprotein-D-Adjuvant Vaccine to Prevent Genital Herpes. NEJM 347: 1652-1661 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»