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Journal of Virology, March 2001, p. 3001-3003, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.3001-3003.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression of Human MxA Protein in Mosquito Cells Interferes with LaCrosse Virus Replication

Tanya A. Miura,1,dagger Jonathan O. Carlson,1 Barry J. Beaty,1,* Richard A. Bowen,2 and Ken E. Olson1

Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology,1 and Animal Reproduction and Biotechnology Laboratory, Department of Physiology,2 Colorado State University, Fort Collins, Colorado 80523

Received 28 August 2000/Accepted 28 November 2000

Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes. In this report, we have shown that transfected mosquito cells expressing the human MxA cDNA are resistant to LAC virus but permissive for Sindbis virus (family Togaviridae) infection.

* Corresponding author. Mailing address: Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-2988. Fax: (970) 491-8323. E-mail: bbeaty{at}cvmbs.colostate.edu.

dagger Present address: National Jewish Medical and Research Center, Denver, CO 80206.

Journal of Virology, March 2001, p. 3001-3003, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.3001-3003.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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  • Kochs, G., Janzen, C., Hohenberg, H., Haller, O. (2002). Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes. Proc. Natl. Acad. Sci. USA 99: 3153-3158 [Abstract] [Full Text]  


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