This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Michaels, M. G.
Right arrow Articles by Rinaldo, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Michaels, M. G.
Right arrow Articles by Rinaldo, C. R., Jr.

 Previous Article  |  Next Article 

Journal of Virology, March 2001, p. 2825-2828, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.2825-2828.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Detection of Infectious Baboon Cytomegalovirus after Baboon-to-Human Liver Xenotransplantation

Marian G. Michaels,1,* Frank J. Jenkins,2 Kirsten St. George,3 Michael A. Nalesnik,4 Thomas E. Starzl,5 and Charles R. Rinaldo Jr.3

Department of Pediatrics, Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Pittsburgh,1 Division of Behavioral Medicine and Oncology, University of Pittsburgh Cancer Institute,2 Department of Pathology, Clinical Virology Laboratory, UPMC-Presbyterian Hospital,3 and Department of Pathology, Division of Transplantation Pathology,4 and Thomas E. Starzl Transplantation Institute,5 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213

Received 22 September 2000/Accepted 22 December 2000

Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known transmissibility and clinical significance of human cytomegalovirus (HCMV) infection after allotransplantation led us to evaluate whether baboon cytomegalovirus (BCMV) transmission could occur after a baboon-to-human liver xenotransplant. We examined serial blood samples from a baboon liver recipient and isolated replication-competent CMV-like agents on days 29, 36, and 42 after xenotransplantation. BCMV and HCMV DNAs were detected in the day 29 isolate, while only HCMV DNA was detected in the other isolates. This is the first report of detecting a replication-competent virus from a source animal after xenotransplantation and is a concern with regard to potential zoonotic transmission to others.

* Corresponding author. Mailing address: Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213-2583. Phone: (412) 692-6768. Fax: (412) 692-8499. E-mail: michaem{at}chplink.chp.edu.

Journal of Virology, March 2001, p. 2825-2828, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.2825-2828.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kalina, T., Lu, H., Zhao, Z., Blewett, E., Dittmer, D. P., Randolph-Habecker, J., Maloney, D. G., Andrews, R. G., Kiem, H.-P., Storek, J. (2005). De novo generation of CD4 T cells against viruses present in the host during immune reconstitution. Blood 105: 2410-2414 [Abstract] [Full Text]  
  • Fryer, J. F. L., Griffiths, P. D., Emery, V. C., Clark, D. A. (2004). Susceptibility of porcine cytomegalovirus to antiviral drugs. J Antimicrob Chemother 53: 975-980 [Abstract] [Full Text]  
  • Whitby, D., Stossel, A., Gamache, C., Papin, J., Bosch, M., Smith, A., Kedes, D. H., White, G., Kennedy, R., Dittmer, D. P. (2003). Novel Kaposi's Sarcoma-Associated Herpesvirus Homolog in Baboons. J. Virol. 77: 8159-8165 [Abstract] [Full Text]  
  • Mueller, N. J., Barth, R. N., Yamamoto, S., Kitamura, H., Patience, C., Yamada, K., Cooper, D. K. C., Sachs, D. H., Kaur, A., Fishman, J. A. (2002). Activation of Cytomegalovirus in Pig-to-Primate Organ Xenotransplantation. J. Virol. 76: 4734-4740 [Abstract] [Full Text]  
  • Chapman, L. E., Bloom, E. T. (2001). Clinical Xenotransplantation. JAMA 285: 2304-2306 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»