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Journal of Virology, March 2001, p. 2825-2828, Vol. 75, No. 6
Department of Pediatrics, Division of
Allergy, Immunology, and Infectious Diseases, Children's Hospital of
Pittsburgh,1 Division of Behavioral
Medicine and Oncology, University of Pittsburgh Cancer
Institute,2 Department of Pathology,
Clinical Virology Laboratory, UPMC-Presbyterian
Hospital,3 and Department of Pathology,
Division of Transplantation Pathology,4 and
Thomas E. Starzl Transplantation
Institute,5 University of Pittsburgh Medical
Center, Pittsburgh, Pennsylvania 15213
Received 22 September 2000/Accepted 22 December 2000
Xenotransplantation is considered to be a solution for the human
donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known
transmissibility and clinical significance of human cytomegalovirus
(HCMV) infection after allotransplantation led us to evaluate whether
baboon cytomegalovirus (BCMV) transmission could occur after a
baboon-to-human liver xenotransplant. We examined serial blood samples
from a baboon liver recipient and isolated replication-competent
CMV-like agents on days 29, 36, and 42 after xenotransplantation. BCMV
and HCMV DNAs were detected in the day 29 isolate, while only HCMV DNA was detected in the other isolates. This is the first report of detecting a replication-competent virus from a source animal after xenotransplantation and is a concern with regard to potential zoonotic
transmission to others.
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.6.2825-2828.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Detection of Infectious Baboon Cytomegalovirus
after Baboon-to-Human Liver Xenotransplantation
*
Corresponding author. Mailing address: Division of
Allergy, Immunology, and Infectious Diseases, Children's Hospital of
Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213-2583. Phone: (412)
692-6768. Fax: (412) 692-8499. E-mail:
michaem{at}chplink.chp.edu.
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