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Journal of Virology, March 2001, p. 2825-2828, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.2825-2828.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Detection of Infectious Baboon Cytomegalovirus after Baboon-to-Human Liver Xenotransplantation

Marian G. Michaels,1,* Frank J. Jenkins,2 Kirsten St. George,3 Michael A. Nalesnik,4 Thomas E. Starzl,5 and Charles R. Rinaldo Jr.3

Department of Pediatrics, Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Pittsburgh,1 Division of Behavioral Medicine and Oncology, University of Pittsburgh Cancer Institute,2 Department of Pathology, Clinical Virology Laboratory, UPMC-Presbyterian Hospital,3 and Department of Pathology, Division of Transplantation Pathology,4 and Thomas E. Starzl Transplantation Institute,5 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213

Received 22 September 2000/Accepted 22 December 2000

Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known transmissibility and clinical significance of human cytomegalovirus (HCMV) infection after allotransplantation led us to evaluate whether baboon cytomegalovirus (BCMV) transmission could occur after a baboon-to-human liver xenotransplant. We examined serial blood samples from a baboon liver recipient and isolated replication-competent CMV-like agents on days 29, 36, and 42 after xenotransplantation. BCMV and HCMV DNAs were detected in the day 29 isolate, while only HCMV DNA was detected in the other isolates. This is the first report of detecting a replication-competent virus from a source animal after xenotransplantation and is a concern with regard to potential zoonotic transmission to others.

* Corresponding author. Mailing address: Division of Allergy, Immunology, and Infectious Diseases, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213-2583. Phone: (412) 692-6768. Fax: (412) 692-8499. E-mail: michaem{at}chplink.chp.edu.

Journal of Virology, March 2001, p. 2825-2828, Vol. 75, No. 6
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.6.2825-2828.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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