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Journal of Virology, March 2001, p. 2472-2474, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2472-2474.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Infrequent Occurrence of Natural Mutations in the pp65495-503 Epitope Sequence Presented by the HLA A*0201 Allele among Human Cytomegalovirus Isolates

John A. Zaia,1,* Ghislaine Gallez-Hawkins,1 Xiuli Li,1 Zhi-Qiang Yao,1,dagger Norma Lomeli,1 Karen Molinder,1 Corinna La Rosa,1,2 and Don J. Diamond1,2

Department of Virology1 and Laboratory of Vaccine Research,2 Beckman Research Institute of the City of Hope, Duarte, California 91010

Received 28 September 2000/Accepted 8 December 2000

To determine if mutations of an immunodominant HLA-restricted cytomegalovirus (CMV) peptide sequence occur in nature, the sequence corresponding to the HLA A*0201-specific peptide CMVpp65495-503 was determined in 50 human CMV isolates. Rare mutations were detected; 6 of 50 were silent mutations at the amino terminus of the peptide, while 3 of 50 were mutations of the native methionine residue to isoleucine (M499I). The observed M499I mutation in three isolates decreased cytolytic targeting.

* Corresponding author. Mailing address: Department of Virology, Beckman Research Institute of the City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010. Phone: (626) 301-8434. Fax: (626) 301-8458. E-mail: jzaia{at}coh.org.

dagger Present address: University of Virginia, Beirne B. Carter Center for Immunology Research, Charlottesville, VA 22908.

Journal of Virology, March 2001, p. 2472-2474, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2472-2474.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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