This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vogel, T. U.
Right arrow Articles by Watkins, D. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vogel, T. U.
Right arrow Articles by Watkins, D. I.

 Previous Article  |  Next Article 

Journal of Virology, March 2001, p. 2458-2461, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2458-2461.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Functional Impairment of Simian Immunodeficiency Virus-Specific CD8+ T Cells during the Chronic Phase of Infection

Thorsten U. Vogel,1 Todd M. Allen,1 John D. Altman,2 and David I. Watkins1,3,*

Wisconsin Regional Primate Research Center1 and Department of Pathology and Laboratory Medicine,3 University of Wisconsin, Madison, Wisconsin 53715, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 303222

Received 2 October 2000/Accepted 7 December 2000

In an attempt to determine why high frequencies of circulating virus-specific CD8+ T cells are unable to control human immunodeficiency virus and simian immunodeficiency virus (SIV) replication, we assessed the functional nature of SIV-specific CD8+ lymphocytes. After vaccination and early after infection, nearly all tetramer-staining CD8+ cells produced gamma interferon in response to their specific stimulus. However, by 4 months postinfection with pathogenic SIVmac239, signs of functional impairment in the CD8+ T-cell compartment were detected which might prevent these T cells from efficiently controlling the infection during the chronic phase.

* Corresponding author. Mailing address: Wisconsin Regional Primate Research Center, 1220 Capitol Ct., Madison, WI 53715. Phone: (608) 265-3380. Fax: (608) 265-8084. E-mail: watkins{at}primate.wisc.edu.

Journal of Virology, March 2001, p. 2458-2461, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2458-2461.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Blattman, J. N., Wherry, E. J., Ha, S.-J., van der Most, R. G., Ahmed, R. (2009). Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection. J. Virol. 83: 4386-4394 [Abstract] [Full Text]  
  • Mason, R. D., Alcantara, S., Peut, V., Loh, L., Lifson, J. D., De Rose, R., Kent, S. J. (2009). Inactivated Simian Immunodeficiency Virus-Pulsed Autologous Fresh Blood Cells as an Immunotherapy Strategy. J. Virol. 83: 1501-1510 [Abstract] [Full Text]  
  • Plesa, G., Snook, A. E., Waldman, S. A., Eisenlohr, L. C. (2008). Derivation and Fluidity of Acutely Induced Dysfunctional CD8+ T Cells. J. Immunol. 180: 5300-5308 [Abstract] [Full Text]  
  • Petrovas, C., Price, D. A., Mattapallil, J., Ambrozak, D. R., Geldmacher, C., Cecchinato, V., Vaccari, M., Tryniszewska, E., Gostick, E., Roederer, M., Douek, D. C., Morgan, S. H., Davis, S. J., Franchini, G., Koup, R. A. (2007). SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110: 928-936 [Abstract] [Full Text]  
  • Agnellini, P., Wolint, P., Rehr, M., Cahenzli, J., Karrer, U., Oxenius, A. (2007). Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. Proc. Natl. Acad. Sci. USA 104: 4565-4570 [Abstract] [Full Text]  
  • Wang, Z., Metcalf, B., Ribeiro, R. M., McClure, H., Kaur, A. (2006). Th-1-Type Cytotoxic CD8+ T-Lymphocyte Responses to Simian Immunodeficiency Virus (SIV) Are a Consistent Feature of Natural SIV Infection in Sooty Mangabeys. J. Virol. 80: 2771-2783 [Abstract] [Full Text]  
  • Loffredo, J. T., Rakasz, E. G., Giraldo, J. P., Spencer, S. P., Grafton, K. K., Martin, S. R., Napoe, G., Yant, L. J., Wilson, N. A., Watkins, D. I. (2005). Tat28-35SL8-Specific CD8+ T Lymphocytes Are More Effective than Gag181-189CM9-Specific CD8+ T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay. J. Virol. 79: 14986-14991 [Abstract] [Full Text]  
  • Miller, N. E., Bonczyk, J. R., Nakayama, Y., Suresh, M. (2005). Role of Thymic Output in Regulating CD8 T-Cell Homeostasis during Acute and Chronic Viral Infection. J. Virol. 79: 9419-9429 [Abstract] [Full Text]  
  • Spada, E, Mele, A, Berton, A, Ruggeri, L, Ferrigno, L, Garbuglia, A R, Perrone, M P, Girelli, G, Del Porto, P, Piccolella, E, Mondelli, M U, Amoroso, P, Cortese, R, Nicosia, A, Vitelli, A, Folgori, A, on behalf of the Acute Hepatitis C Italian Study G, (2004). Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut 53: 1673-1681 [Abstract] [Full Text]  
  • Loffredo, J. T., Sidney, J., Wojewoda, C., Dodds, E., Reynolds, M. R., Napoe, G., Mothe, B. R., O'Connor, D. H., Wilson, N. A., Watkins, D. I., Sette, A. (2004). Identification of Seventeen New Simian Immunodeficiency Virus-Derived CD8+ T Cell Epitopes Restricted by the High Frequency Molecule, Mamu-A*02, and Potential Escape from CTL Recognition. J. Immunol. 173: 5064-5076 [Abstract] [Full Text]  
  • Lun, W.-H., Takeda, A., Nakamura, H., Kano, M., Mori, K., Sata, T., Nagai, Y., Matano, T. (2004). Loss of virus-specific CD4+ T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques. J. Gen. Virol. 85: 1955-1963 [Abstract] [Full Text]  
  • Wherry, E. J., Ahmed, R. (2004). Memory CD8 T-Cell Differentiation during Viral Infection. J. Virol. 78: 5535-5545 [Full Text]  
  • Suresh, M., Gao, X., Fischer, C., Miller, N. E., Tewari, K. (2004). Dissection of Antiviral and Immune Regulatory Functions of Tumor Necrosis Factor Receptors in a Chronic Lymphocytic Choriomeningitis Virus Infection. J. Virol. 78: 3906-3918 [Abstract] [Full Text]  
  • Abel, K., La Franco-Scheuch, L., Rourke, T., Ma, Z.-M., de Silva, V., Fallert, B., Beckett, L., Reinhart, T. A., Miller, C. J. (2004). Gamma Interferon-Mediated Inflammation Is Associated with Lack of Protection from Intravaginal Simian Immunodeficiency Virus SIVmac239 Challenge in Simian-Human Immunodeficiency Virus 89.6-Immunized Rhesus Macaques. J. Virol. 78: 841-854 [Abstract] [Full Text]  
  • Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R., Ahmed, R. (2003). Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment. J. Virol. 77: 4911-4927 [Abstract] [Full Text]  
  • Fitzgerald, J. C., Gao, G.-P., Reyes-Sandoval, A., Pavlakis, G. N., Xiang, Z. Q., Wlazlo, A. P., Giles-Davis, W., Wilson, J. M., Ertl, H. C. J. (2003). A Simian Replication-Defective Adenoviral Recombinant Vaccine to HIV-1 Gag. J. Immunol. 170: 1416-1422 [Abstract] [Full Text]  
  • Zhang, D., Shankar, P., Xu, Z., Harnisch, B., Chen, G., Lange, C., Lee, S. J., Valdez, H., Lederman, M. M., Lieberman, J. (2003). Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood 101: 226-235 [Abstract] [Full Text]  
  • Hel, Z., Nacsa, J., Tryniszewska, E., Tsai, W.-P., Parks, R. W., Montefiori, D. C., Felber, B. K., Tartaglia, J., Pavlakis, G. N., Franchini, G. (2002). Containment of Simian Immunodeficiency Virus Infection in Vaccinated Macaques: Correlation with the Magnitude of Virus-Specific Pre- and Postchallenge CD4+ and CD8+ T Cell Responses. J. Immunol. 169: 4778-4787 [Abstract] [Full Text]  
  • Tryniszewska, E., Nacsa, J., Lewis, M. G., Silvera, P., Montefiori, D., Venzon, D., Hel, Z., Parks, R. W., Moniuszko, M., Tartaglia, J., Smith, K. A., Franchini, G. (2002). Vaccination of Macaques with Long-Standing SIVmac251 Infection Lowers the Viral Set Point After Cessation of Antiretroviral Therapy. J. Immunol. 169: 5347-5357 [Abstract] [Full Text]  
  • Vogel, T. U., Horton, H., Fuller, D. H., Carter, D. K., Vielhuber, K., O'Connor, D. H., Shipley, T., Fuller, J., Sutter, G., Erfle, V., Wilson, N., Picker, L. J., Watkins, D. I. (2002). Differences Between T Cell Epitopes Recognized After Immunization and After Infection. J. Immunol. 169: 4511-4521 [Abstract] [Full Text]  
  • Wedemeyer, H., He, X.-S., Nascimbeni, M., Davis, A. R., Greenberg, H. B., Hoofnagle, J. H., Liang, T. J., Alter, H., Rehermann, B. (2002). Impaired Effector Function of Hepatitis C Virus-Specific CD8+ T Cells in Chronic Hepatitis C Virus Infection. J. Immunol. 169: 3447-3458 [Abstract] [Full Text]  
  • Horton, H., Vogel, T. U., Carter, D. K., Vielhuber, K., Fuller, D. H., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Montefiori, D. C., Erfle, V., Desrosiers, R. C., Wilson, N., Picker, L. J., Wolinsky, S. M., Wang, C., Allison, D. B., Watkins, D. I. (2002). Immunization of Rhesus Macaques with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen Induces Broad Simian Immunodeficiency Virus (SIV)-Specific T-Cell Responses and Reduces Initial Viral Replication but Does Not Prevent Disease Progression following Challenge with Pathogenic SIVmac239. J. Virol. 76: 7187-7202 [Abstract] [Full Text]  
  • Kostense, S., Vandenberghe, K., Joling, J., Van Baarle, D., Nanlohy, N., Manting, E., Miedema, F. (2002). Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-gamma + HIV-specific T cells during progression to AIDS. Blood 99: 2505-2511 [Abstract] [Full Text]  
  • Ansari, A. A., Mayne, A. E., Sundstrom, J. B., Bostik, P., Grimm, B., Altman, J. D., Villinger, F. (2002). Administration of Recombinant Rhesus Interleukin-12 during Acute Simian Immunodeficiency Virus (SIV) Infection Leads to Decreased Viral Loads Associated with Prolonged Survival in SIVmac251-Infected Rhesus Macaques. J. Virol. 76: 1731-1743 [Abstract] [Full Text]  
  • McKay, P. F., Schmitz, J. E., Barouch, D. H., Kuroda, M. J., Lifton, M. A., Nickerson, C. E., Gorgone, D. A., Letvin, N. L. (2002). Vaccine Protection Against Functional CTL Abnormalities in Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys. J. Immunol. 168: 332-337 [Abstract] [Full Text]  
  • Hel, Z., Nacsa, J., Kelsall, B., Tsai, W.-P., Letvin, N., Parks, R. W., Tryniszewska, E., Picker, L., Lewis, M. G., Edghill-Smith, Y., Moniuszko, M., Pal, R., Stevceva, L., Altman, J. D., Allen, T. M., Watkins, D., Torres, J. V., Berzofsky, J. A., Belyakov, I. M., Strober, W., Franchini, G. (2001). Impairment of Gag-Specific CD8+ T-Cell Function in Mucosal and Systemic Compartments of Simian Immunodeficiency Virus mac251- and Simian-Human Immunodeficiency Virus KU2-Infected Macaques. J. Virol. 75: 11483-11495 [Abstract] [Full Text]  
  • Eo, S. K., Kumaraguru, U., Rouse, B. T. (2001). Plasmid DNA Encoding CCR7 Ligands Compensate for Dysfunctional CD8+ T Cell Responses by Effects on Dendritic Cells. J. Immunol. 167: 3592-3599 [Abstract] [Full Text]  
  • Lieberman, J., Shankar, P., Manjunath, N., Andersson, J. (2001). Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood 98: 1667-1677 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»