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Journal of Virology, March 2001, p. 2059-2066, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2059-2066.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Exposure of Hepatitis C Virus (HCV) RNA-Positive Recipients to HCV RNA-Positive Blood Donors Results in Rapid Predominance of a Single Donor Strain and Exclusion and/or Suppression of the Recipient Strain

Tomasz Laskus,1,* Lian-Fu Wang,2 Marek Radkowski,1,3 Hugo Vargas,2 Marek Nowicki,4 Jeffrey Wilkinson,1 and Jorge Rakela1

Division of Transplantation Medicine, Mayo Clinic Scottsdale, Scottsdale, Arizona 852591; Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 152132; Institute of Infectious Diseases, Medical Academy, Warsaw, Poland3; and Transfusion Viruses Studies, University of Southern California, Los Angeles, California 900894

Received 14 July 2000/Accepted 22 November 2000

We have analyzed three cases of hepatitis C virus (HCV)-infected recipients who received blood from HCV-infected donors. Two recipients were exposed to two different HCV RNA-positive donors, and one was exposed to a single donor. All parental genomes from the actual infecting units of blood and the recipients were defined, and their presence in the follow-up serum samples was determined using sensitive strain-specific assays. The strain from one of the donors was found to predominate in all recipients' serum samples collected throughout the follow-up period of 10 to 30 months. In two recipients exposed to two infected donors, the strain from the second donor was occasionally found at very low level. However, the original recipients' strains were not detected. Our observations show that HCV-infected individuals can be superinfected with different strains, and this event may lead to eradication or suppression of the original infecting strain. Furthermore, our findings demonstrate that simultaneous exposure to multiple HCV strains may result in concomitant infection by more than one strain, although a single strain could rapidly establish its dominance. The results of the present study suggest the existence of competition among infecting HCV strains which determines the ultimate outcome of multiple HCV exposure.

* Corresponding author. Mailing address: SC Johnson Bldg. Sj-3, Mayo Clinic Scottsdale, 13400 East Shea Blvd., Scottsdale, AZ 85259. Phone: (480) 301-6370. Fax: (480) 301-3384. E-mail: laskus.tomasz{at}mayo.edu.

Journal of Virology, March 2001, p. 2059-2066, Vol. 75, No. 5
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.5.2059-2066.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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