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Journal of Virology, February 2001, p. 1990-1995, Vol. 75, No. 4
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.4.1990-1995.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mucosal Transmission and Induction of Simian AIDS by CCR5-Specific Simian/Human Immunodeficiency Virus SHIVSF162P3

Janet M. Harouse,1,* Agegnehu Gettie,1 Tadesse Eshetu,1 Rei Chin How Tan,1 Rudolf Bohm,2 James Blanchard,2 Gary Baskin,2 and Cecilia Cheng-Mayer1

Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016,1 and Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 704332

Received 14 July 2000/Accepted 9 November 2000

Nonhuman primate models are increasingly used in the screening of candidate AIDS vaccine and immunization strategies for advancement to large-scale human trials. The predictive value of such macaque studies is largely dependent upon the fidelity of the model system in mimicking human immunodeficiency virus (HIV) type 1 infection in terms of viral transmission, replication, and pathogenesis. Herein, we describe the efficient mucosal transmission of a CCR5-specific chimeric simian/human immunodeficiency virus, SHIVSF162P3. Female rhesus macaques were infected with SHIVSF162P3 after a single atraumatic application to the cervicovaginal mucosa. The disease course of SHIVSF162P3-infected monkeys is similar and as varied as natural HIV infection in terms of viral replication, gradual loss of CD4+ peripheral blood mononuclear cells, and the development of simian AIDS-defining opportunistic infections. The SHIVSF162P3/macaque model should facilitate direct preclinical assessment of HIV vaccine strategies in addition to antiviral compounds directed towards envelope target cell interactions. Furthermore, this controlled model provides the setting to investigate immunologic responses and putative host-specific susceptibility factors that alter viral transmission and subsequent disease progression.

* Corresponding author. Mailing address: Aaron Diamonds AIDS Research Center, 455 First Ave., New York, New York 10016. Phone: (212) 448-5083. Fax: (212) 448-5159. E-mail: JHarouse{at}ADARC.org.

Journal of Virology, February 2001, p. 1990-1995, Vol. 75, No. 4
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.4.1990-1995.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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