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Journal of Virology, February 2001, p. 1620-1631, Vol. 75, No. 4
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.4.1620-1631.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Porcine Teschoviruses Comprise at Least Eleven
Distinct Serotypes: Molecular and Evolutionary Aspects
Roland
Zell,1,*
Malte
Dauber,2
Andi
Krumbholz,1
Andreas
Henke,1
Eckhard
Birch-Hirschfeld,1
Axel
Stelzner,1
Dieter
Prager,3 and
Rudiger
Wurm3
Institut für Virologie, Klinikum der
Friedrich-Schiller-Universität, 07745 Jena,1 Bundesforschungsanstalt für
Viruskrankheiten der Tiere, Friedrich-Loeffler-Institut, Institut
für Virusdiagnostik, 17498 Insel
Riems,2 and Staatliches
Veterinäruntersuchungsamt, 59821 Arnsberg,3 Germany
Received 10 August 2000/Accepted 14 November 2000
Nucleotide sequencing and phylogenetic analysis of 10 recognized
prototype strains of the porcine enterovirus (PEV) cytopathic effect
(CPE) group I reveals a close relationship of the viral genomes to the
previously sequenced strain F65, supporting the concept of a
reclassification of this virus group into a new picornavirus genus.
Also, nucleotide sequences of the polyprotein-encoding genome region or
the P1 region of 28 historic strains and recent field isolates were
determined. The data suggest that several closely related but
antigenically and molecular distinct serotypes constitute one species
within the proposed genus Teschovirus. Based on sequence
data and serological data, we propose a new serotype with strain
Dresden as prototype. This hitherto unrecognized serotype is closely
related to porcine teschovirus 1 (PTV-1, former PEV-1), but induces
type-specific neutralizing antibodies. Sequencing of field isolates
collected from animals presenting with neurological disorders prove
that other serotypes than PTV-1 may also cause polioencephalomyelitis
of swine.
*
Corresponding author. Mailing address: Institut
für Virologie, Klinikum der Friedrich-Schiller-Universität,
Winzerlaer Str. 10, 07745 Jena, Germany. Phone: (49) 3641-657209. Fax:
(49) 3641-657202. E-mail: i6zero{at}rz.uni-jena.de.
Journal of Virology, February 2001, p. 1620-1631, Vol. 75, No. 4
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.4.1620-1631.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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