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Journal of Virology, February 2001, p. 1551-1556, Vol. 75, No. 3
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.3.1551-1556.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Emergence in Asia of Foot-and-Mouth Disease Viruses with Altered Host Range: Characterization of Alterations in the 3A Protein

Nick J. Knowles,1 Paul R. Davies,1 Tina Henry,2 Vivian O'Donnell,2 Juan M. Pacheco,2 and Peter W. Mason2,*

Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 ONF, United Kingdom,1 and Plum Island Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Greenport, New York 119442

Received 13 July 2000/Accepted 26 October 2000

In 1997, an epizootic in Taiwan, Province of China, was caused by a type O foot-and-mouth disease virus which infected pigs but not cattle. The virus had an altered 3A protein, which harbored a 10-amino-acid deletion and a series of substitutions. Here we show that this deletion is present in the earliest type O virus examined from the region (from 1970), whereas substitutions surrounding the deletion accumulated over the last 29 years. Analyses of the growth of these viruses in bovine cells suggest that changes in the genome in addition to the deletion, per se, are responsible for the porcinophilic properties of current Asian viruses in this lineage.

* Corresponding author. Mailing address: Plum Island Animal Disease Center, USDA, ARS, P.O. Box 848, Greenport, NY 11944. Phone: (631) 323-3177. Fax: (631) 323-2507. E-mail: pwmason{at}piadc.ars.usda.gov.

Journal of Virology, February 2001, p. 1551-1556, Vol. 75, No. 3
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.3.1551-1556.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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