DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162{Delta}V2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8+ T-Cell-Depleted Rhesus Macaques

doi:10.1128/JVI.75.3.1547-1550.2001

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Journal of Virology, February 2001, p. 1547-1550, Vol. 75, No. 3
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.3.1547-1550.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162 $Delta$ V2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8⁺ T-Cell-Depleted Rhesus Macaques

S. Cherpelis,¹ I. Shrivastava,² A. Gettie,¹^,³ X. Jin,¹ D. D. Ho,¹ S. W. Barnett,² and L. Stamatatos¹^,^*

Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021-6399¹; Chiron Corporation, Emeryville, California 94608-2916²; and Tulane Regional Primate Research Center, Covington, Louisiana 70433³

Received 14 July 2000/Accepted 30 October 2000

DNA immunization of macaques with the SF162 $Delta$ V2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies.The animals were depleted of their CD8⁺ T lymphocytes and then challenged intravenously with SHIV162P4.Compared to unvaccinated animals, the vaccinated macaques hadlower peak viremia levels, rapidly cleared plasma virus, and showeddelayedseroconversion.

^* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 First Ave., 7th floor, New York, NY 10016.Phone: (212) 448-5000. Fax: (212) 725-1126. E-mail: 1stamata{at}adarc.org.

Journal of Virology, February 2001, p. 1547-1550, Vol. 75, No. 3
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.3.1547-1550.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162V2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8+ T-Cell-Depleted Rhesus Macaques

DNA Vaccination with the Human Immunodeficiency Virus Type 1 SF162 $Delta$ V2 Envelope Elicits Immune Responses That Offer Partial Protection from Simian/Human Immunodeficiency Virus Infection to CD8⁺ T-Cell-Depleted Rhesus Macaques