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Journal of Virology, December 2001, p. 11935-11938, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11935-11938.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Segregation of EAV-HP Ancient Endogenous Retroviruses within the Chicken Population

M. A. Sacco and K. Venugopal*

Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom

Received 11 June 2001/Accepted 13 September 2001

Avian leukosis virus subgroup J (ALV-J), an exogenous avian retrovirus, is thought to have evolved by recombination with the highly identical env gene of the endogenous avian retrovirus EAV-HP. Embryonic expression of EAV-HP env has been suggested to be associated with the induction of immunological tolerance, a feature observed in a significant proportion of meat-type chickens infected with ALV-J. In support of this hypothesis, we demonstrate that EAV-HP loci, some of which could be associated with tolerance, are still segregating within the chicken population.

* Corresponding author. Mailing address: Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom. Phone: 44 (0)1635-578411. Fax: 44 (0)1635-577237. E-mail: venu.gopal{at}bbsrc.ac.uk.

Journal of Virology, December 2001, p. 11935-11938, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11935-11938.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Sacco, M. A., Howes, K., Smith, L. P., Nair, V. K. (2004). Assessing the Roles of Endogenous Retrovirus EAV-HP in Avian Leukosis Virus Subgroup J Emergence and Tolerance. J. Virol. 78: 10525-10535 [Abstract] [Full Text]  
  • Denesvre, C., Soubieux, D., Pin, G., Hue, D., Dambrine, G. (2003). Interference between avian endogenous ev/J 4.1 and exogenous ALV-J retroviral envelopes. J. Gen. Virol. 84: 3233-3238 [Abstract] [Full Text]  


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