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Journal of Virology, December 2001, p. 11897-11901, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11897-11901.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

An N-Terminal Domain of Herpes Simplex Virus Type I gE Is Capable of Forming Stable Complexes with gI

Syed Monem Rizvi and Malini Raghavan*

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109-0620

Received 1 May 2001/Accepted 24 August 2001

Using limited proteolytic analyses, we show that gE present in soluble herpes simplex virus type 1 gE-gI complexes is cleaved into a C-terminal (CgE) and an N-terminal (NgE) domain. The domain boundary is in the vicinity of residue 188 of mature gE. NgE, but not CgE, forms a stable complex with soluble gI.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, 5641 Medical Science Building II, University of Michigan Medical School, Ann Arbor, MI 48109-0620. Phone: (734) 647-7752. Fax: (734) 764-3562. E-mail: malinir{at}umich.edu.

Journal of Virology, December 2001, p. 11897-11901, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11897-11901.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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