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Journal of Virology, December 2001, p. 11886-11890, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11886-11890.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interleukin-4 Up-Regulates Mouse Mammary Tumor Virus Expression yet Is Not Required for In Vivo Virus Spread

Jennifer Czarneski,1 Jennifer Meyers,1 Tao Peng,1,dagger Valsamma Abraham,1,Dagger Rosemarie Mick,2 and Susan R. Ross1,*

Department of Microbiology1 and Center for Clinical Epidemiology and Biostatistics,2 Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6142

Received 20 April 2001/Accepted 28 August 2001

The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

* Corresponding author. Mailing address: 313BRB2, 421 Curie Blvd., Philadelphia, PA 19104. Phone: (215) 898-9764. Fax: (215) 573-2028. E-mail: rosss{at}mail.med.upenn.edu.

dagger Present address: Whitehead Institute, Cambridge, MA 02142.

Dagger Present address: Department of Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.

Journal of Virology, December 2001, p. 11886-11890, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11886-11890.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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