This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sironen, T.
Right arrow Articles by Plyusnin, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sironen, T.
Right arrow Articles by Plyusnin, A.

 Previous Article  |  Next Article 

Journal of Virology, December 2001, p. 11803-11810, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11803-11810.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Molecular Evolution of Puumala Hantavirus

Tarja Sironen, Antti Vaheri,* and Alexander Plyusnin

Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland

Received 21 June 2001/Accepted 29 August 2001

Puumala virus (PUUV) is a negative-stranded RNA virus in the genus Hantavirus, family Bunyaviridae. In this study, detailed phylogenetic analysis was performed on 42 complete S segment sequences of PUUV originated from several European countries, Russia, and Japan, the largest set available thus far for hantaviruses. The results show that PUUV sequences form seven distinct and well-supported genetic lineages; within these lineages, geographical clustering of genetic variants is observed. The overall phylogeny of PUUV is star-like, suggesting an early split of genetic lineages. The individual PUUV lineages appear to be independent, with the only exception to this being the Finnish and the Russian lineages that are closely connected to each other. Two strains of PUUV-like virus from Japan form the most ancestral lineage diverging from PUUV. Recombination points within the S segment were searched for and evidence for intralineage recombination events was seen in the Finnish, Russian, Danish, and Belgian lineages of PUUV. Molecular clock analysis showed that PUUV is a stable virus, evolving slowly at a rate of 0.7 × 10-7 to 2.2 × 10-6 nt substitutions per site per year.

* Corresponding author. Mailing address: Haartman Institute, Department of Virology, Haartmaninkatu 3, POB 21, FIN-00014 University of Helsinki, Finland. Phone: 358-9-1912 6490. Fax: 358-9-1912 6491. E-mail: Antti.Vaheri{at}helsinki.fi.

Journal of Virology, December 2001, p. 11803-11810, Vol. 75, No. 23
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.23.11803-11810.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Razzauti, M., Plyusnina, A., Sironen, T., Henttonen, H., Plyusnin, A. (2009). Analysis of Puumala hantavirus in a bank vole population in northern Finland: evidence for co-circulation of two genetic lineages and frequent reassortment between strains. J. Gen. Virol. 90: 1923-1931 [Abstract] [Full Text]  
  • Medina, R. A., Torres-Perez, F., Galeno, H., Navarrete, M., Vial, P. A., Palma, R. E., Ferres, M., Cook, J. A., Hjelle, B. (2009). Ecology, Genetic Diversity, and Phylogeographic Structure of Andes Virus in Humans and Rodents in Chile. J. Virol. 83: 2446-2459 [Abstract] [Full Text]  
  • Ramsden, C., Holmes, E. C., Charleston, M. A. (2009). Hantavirus Evolution in Relation to Its Rodent and Insectivore Hosts: No Evidence for Codivergence. Mol Biol Evol 26: 143-153 [Abstract] [Full Text]  
  • Zou, Y., Hu, J., Wang, Z.-X., Wang, D.-M., Li, M.-H., Ren, G.-D., Duan, Z.-X., Fu, Z. F., Plyusnin, A., Zhang, Y.-Z. (2008). Molecular diversity and phylogeny of Hantaan virus in Guizhou, China: evidence for Guizhou as a radiation center of the present Hantaan virus. J. Gen. Virol. 89: 1987-1997 [Abstract] [Full Text]  
  • Razzauti, M., Plyusnina, A., Henttonen, H., Plyusnin, A. (2008). Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population. J. Gen. Virol. 89: 1649-1660 [Abstract] [Full Text]  
  • Ramsden, C., Melo, F. L., Figueiredo, Luiz. M., Holmes, E. C., Zanotto, P. M.A., the VGDN Consortium, (2008). High Rates of Molecular Evolution in Hantaviruses. Mol Biol Evol 25: 1488-1492 [Abstract] [Full Text]  
  • Sironen, T., Kallio, E. R., Vaheri, A., Lundkvist, A., Plyusnin, A. (2008). Quasispecies dynamics and fixation of a synonymous mutation in hantavirus transmission. J. Gen. Virol. 89: 1309-1313 [Abstract] [Full Text]  
  • Norberg, P., Kasubi, M. J., Haarr, L., Bergstrom, T., Liljeqvist, J.-A. (2007). Divergence and Recombination of Clinical Herpes Simplex Virus Type 2 Isolates. J. Virol. 81: 13158-13167 [Abstract] [Full Text]  
  • Song, K.-J., Baek, L. J., Moon, S., Ha, S. J., Kim, S. H., Park, K. S., Klein, T. A., Sames, W., Kim, H.-C., Lee, J. S., Yanagihara, R., Song, J.-W. (2007). Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea. J. Gen. Virol. 88: 3121-3129 [Abstract] [Full Text]  
  • Tan, Z., Wada, Y., Chen, J., Ohshima, K. (2004). Inter- and intralineage recombinants are common in natural populations of Turnip mosaic virus. J. Gen. Virol. 85: 2683-2696 [Abstract] [Full Text]  
  • Chare, E. R., Gould, E. A., Holmes, E. C. (2003). Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses. J. Gen. Virol. 84: 2691-2703 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»