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Journal of Virology, November 2001, p. 11218-11221, Vol. 75, No. 22
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.22.11218-11221.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Human Cytomegalovirus Open Reading Frame TRL11/IRL11 Encodes an Immunoglobulin G Fc-Binding Protein

Brendan N. Lilley, Hidde L. Ploegh,* and Rebecca S. Tirabassi

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Received 16 May 2001/Accepted 20 August 2001

Several herpesviruses encode Fc receptors that may play a role in preventing antibody-mediated clearance of the virus in vivo. Human cytomegalovirus (HCMV) induces an Fc-binding activity in cells upon infection, but the gene that encodes this Fc-binding protein has not been identified. Here, we demonstrate that the HCMV AD169 open reading frame TRL11 and its identical copy, IRL11, encode a type I membrane glycoprotein that possesses IgG Fc-binding capabilities.

* Corresponding author. Mailing address: Department of Pathology, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115. Phone: (617) 432-4776. Fax: (617) 432-4775. E-mail: ploegh{at}hms.harvard.edu.

Journal of Virology, November 2001, p. 11218-11221, Vol. 75, No. 22
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.22.11218-11221.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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