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Journal of Virology, November 2001, p. 11025-11033, Vol. 75, No. 22
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.22.11025-11033.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Infection and Activation of Monocytes by Marburg and Ebola Viruses

Ute Ströher,1 Elmar West,1 Harald Bugany,1 Hans-Dieter Klenk,1 Hans-Joachim Schnittler,2 and Heinz Feldmann1,3,*

Institut für Virologie, Philipps-Universität, D-35037 Marburg,1 and Institut für Physiologie und Pathophysiologie, Carl-Gustav-Carus-Universität, D-01307 Dresden,2 Germany, and Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba R3E 3R2, Canada3

Received 18 July 2001/Accepted 26 July 2001

In this study we investigated the effects of Marburg virus and Ebola virus (species Zaire and Reston) infections on freshly isolated suspended monocytes in comparison to adherent macrophages under culture conditions. Our data showed that monocytes are permissive for both filoviruses. As is the case in macrophages, infection resulted in the activation of monocytes which was largely independent of virus replication. The activation was triggered similarly by Marburg and Ebola viruses, species Zaire and Reston, as indicated by the release of the proinflammatory cytokines interleukin-1beta (IL-1beta ), tumor necrosis factor alpha , and IL-6 as well as the chemokines IL-8 and gro-alpha . Our data suggest that infected monocytes may play an important role in the spread of filoviruses and in the pathogenesis of filoviral hemorrhagic disease.

* Corresponding author. Mailing address: Canadian Science Centre for Human and Animal Health, 1015 Arlington St., Winnipeg, Manitoba R3E 3R2, Canada. Phone: (204) 789-6019. Fax: (204) 789-2140. E-mail: Heinz_Feldmann{at}hc-sc.gc.ca.

Journal of Virology, November 2001, p. 11025-11033, Vol. 75, No. 22
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.22.11025-11033.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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