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Journal of Virology, November 2001, p. 10550-10556, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10550-10556.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Sequence Conservation and Antigenic Variation of the Structural Proteins of Equine Rhinitis A Virus

Annalisa Varrasso,1 Heidi E. Drummer,2 Jin-an Huang,1 Rachel A. Stevenson,1 Nino Ficorilli,1 Michael J. Studdert,1 and Carol A. Hartley1,*

Centre for Equine Virology, School of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010,1 and St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065,2 Australia

Received 27 February 2001/Accepted 31 July 2001

The nucleotide and deduced amino acid sequences of the P1 region of the genomes of 10 independent equine rhinitis A virus (ERAV) isolates were determined and found to be very closely related. A panel of seven monoclonal antibodies to the prototype virus ERAV.393/76 that bound to nonneutralization epitopes conserved among all 10 isolates was raised. In serum neutralization assays, rabbit polyclonal sera and sera from naturally and experimentally infected horses reacted in a consistent and discriminating manner with the 10 isolates, which indicated the existence of variation in the neutralization epitopes of these viruses.

* Corresponding author. Mailing address: Centre for Equine Virology, School of Veterinary Science, The University of Melbourne, Park Dr. and Flemington Rd., Parkville, Victoria 3010, Australia. Phone: 61 3 8344 7375. Fax: 61 3 8344 7374. E-mail: carolah{at}unimelb.edu.au.

Journal of Virology, November 2001, p. 10550-10556, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10550-10556.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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