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Journal of Virology, November 2001, p. 10523-10526, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10523-10526.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

DC-SIGN Interactions with Human Immunodeficiency Virus: Virus Binding and Transfer Are Dissociable Functions

Stefan Pöhlmann,1 George J. Leslie,1 Terri G. Edwards,1 Todd Macfarlan,1 Jacqueline D. Reeves,1 Kirsten Hiebenthal-Millow,2 Frank Kirchhoff,2,dagger Frédéric Baribaud,1 and Robert W. Doms1,*

Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104,1 and University of Erlangen-Nürnberg, 91054 Erlangen, Germany2

Received 31 May 2001/Accepted 2 August 2001

The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.

* Corresponding author. Mailing address: Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 36th and Hamilton Walk, Philadelphia, PA 19104. Phone: (215) 898-0890. Fax: (215) 573-2883. E-mail: doms{at}mail.med.upenn.edu.

dagger Present address: Abteilung Virologie, Institut für Mikrobiologie und Immunologie, Universitätsklinikum Ulm, 89081 Ulm, Germany.

Journal of Virology, November 2001, p. 10523-10526, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10523-10526.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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