Previous Article | Next Article ![]()
Journal of Virology, November 2001, p. 10523-10526, Vol. 75, No. 21
Department of Microbiology, University of
Pennsylvania, Philadelphia, Pennsylvania
19104,1 and University of
Erlangen-Nürnberg, 91054 Erlangen, Germany2
Received 31 May 2001/Accepted 2 August 2001
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human
immunodeficiency virus (HIV) to susceptible cells, although the
underlying mechanism is unclear. Here we show that
DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding
and transfer steps, indicating that efficient virus transmission is not
simply due to tethering of virus to the cell surface.
0022-538X/01/$04.00+0 DOI: 10.1128/JVI.75.21.10523-10526.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
DC-SIGN Interactions with Human Immunodeficiency
Virus: Virus Binding and Transfer Are Dissociable Functions

*
Corresponding author. Mailing address: Department of
Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 36th and Hamilton Walk, Philadelphia, PA 19104. Phone: (215) 898-0890. Fax:
(215) 573-2883. E-mail: doms{at}mail.med.upenn.edu.
Present address: Abteilung Virologie, Institut für
Mikrobiologie und Immunologie, Universitätsklinikum Ulm, 89081 Ulm, Germany.
This article has been cited by other articles:
| J. Bacteriol. | Mol. Cell. Biol. | Microbiol. Mol. Biol. Rev. |
|---|
| Clin. Vaccine Immunol. | ALL ASM JOURNALS |
|---|