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Journal of Virology, November 2001, p. 10520-10522, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10520-10522.2001

Human Immunodeficiency Virus Type 1 (HIV-1) Non-B Subtypes Are Similar to HIV-1 Subtype B in that Coreceptor Specificity Is a Determinant of Cytopathicity in Human Lymphoid Tissue Infected Ex Vivo

Nina Malkevich,1 Chad Womack,2,* Punita Pandya,2 Jean-Charles Grivel,1 Anthony S. Fauci,2 and Leonid Margolis1

Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development,1 and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases,2 National Institutes of Health, Bethesda, Maryland 20892

Received 22 November 2000/Accepted 1 August 2001

We sought to determine the relationship between virus-mediated CD4+ T-lymphocyte cytopathicity and viral coreceptor preference among various human immunodeficiency virus type 1 (HIV-1) subtypes in an ex vivo-infected human lymphoid tissue model. Our data show that all R5 HIV-1 infections resulted in mild depletion of CD4+ T lymphocytes, whereas all X4 HIV-1 infections caused severe depletion of CD4+ T lymphocytes regardless of their subtype origin. Thus, at least for the viruses within subtypes A, B, C, and E that were tested, coreceptor specificity is a critical factor that determines the ability of HIV-1 to deplete CD4+ T cells in human lymphoid tissue infected ex vivo.

* Corresponding author. Mailing address: Bldg. 10, Rm. 6A11, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-1576. Phone: (301) 402-9015. Fax: (301) 435-3339. E-mail: cwomack{at}niaid.nih.gov.

Journal of Virology, November 2001, p. 10520-10522, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10520-10522.2001


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