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Journal of Virology, November 2001, p. 10511-10514, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10511-10514.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Productive Infection of Primary Macrophages with Human Herpesvirus 7

Ying Zhang,1 Leen de Bolle,1 Stefano Aquaro,1,dagger Alfons van Lommel,2 Erik De Clercq,1 and Dominique Schols1,*

Rega Institute for Medical Research1 and Department of Morphology and Molecular Pathology,2 Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Received 14 June 2000/Accepted 6 August 2001

Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1 month after infection. Thus, macrophages become infected by HHV-7 and might play an important role as a viral reservoir, as has been demonstrated for human immunodeficiency virus type 1.

* Corresponding author. Mailing address: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. Phone: 32-16-337341. Fax: 32-16-337340. E-mail: Dominique.Schols{at}rega.kuleuven.ac.be.

dagger Permanent address: Department of Experimental Medicine, University of Rome "Tor Vergata," Rome, Italy.

Journal of Virology, November 2001, p. 10511-10514, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10511-10514.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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