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Journal of Virology, November 2001, p. 10505-10510, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10505-10510.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Isomerization of a Uniquely Designed Amplicon during Herpes Simplex Virus-Mediated Replication

Hua Wang,1 Xinping Fu,1 and Xiaoliu Zhang1,2,*

Center for Cell and Gene Therapy1 and Departments of Pediatrics and Molecular Virology & Microbiology,2 Baylor College of Medicine, Houston, Texas 77030

Received 18 April 2001/Accepted 22 July 2001

Herpes simplex virus (HSV) type 1 DNA isomerization was studied using a uniquely designed amplicon that mimics the viral genomic structure. The results revealed that amplicon concatemers frequently contain adjacent amplicon units with their segments in opposed orientations. These unusual concatemers were generated through homologous recombination, which does not require HSV DNA as the source of homology.

* Corresponding author. Mailing address: Department of Pediatrics and Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. Phone: (713) 798-1256. Fax: (713) 798-1230. E-mail: xzhang{at}bcm.tmc.edu.

Journal of Virology, November 2001, p. 10505-10510, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10505-10510.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.