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Journal of Virology, November 2001, p. 10467-10471, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10467-10471.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Role of Tachykinins in the Host Response to Murine Gammaherpesvirus Infection

Catherine M. Payne,dagger Caroline J. Heggie, David G. Brownstein, James P. Stewart,* and John P. QuinnDagger

Laboratory for Clinical and Molecular Virology, The University of Edinburgh, Edinburgh EH9 1QH, United Kingdom

Received 29 May 2001/Accepted 26 July 2001

Tachykinins function not only as neurotransmitters but also as immunological mediators. We used infection of tachykinin-deficient (PPT-A-/-) mice and wild-type controls with murine gammaherpesvirus to assess the role of tachykinins in the host response to a virus infection. Although infection was ultimately controlled in PPT-A-/- mice, there were higher titers of infectious virus in the lungs, accompanied by a more rapid influx of inflammatory cells. Clearance of latently infected cells from the spleen was also delayed. This is the first report of the direct influence of tachykinins in the host response to a virus infection.

* Corresponding author. Mailing address: Laboratory for Clinical and Molecular Virology, The University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom. Phone: 44 131 650 7939. Fax: 44 131 650 6511. E-mail: james.stewart{at}ed.ac.uk.

dagger Present address: Department of Pathology, The University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.

Dagger Present address: Physiological Laboratory and Department of Human Anatomy and Cell Biology, University of Liverpool, Liverpool L69 3BX, United Kingdom.

Journal of Virology, November 2001, p. 10467-10471, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10467-10471.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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