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Journal of Virology, November 2001, p. 10455-10459, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10455-10459.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immunodeficiency Virus Type 1 Variants on Different CD4+-T-Cell Subsets Are Determined Only by Coreceptor Expression

David Kwa, Jose Vingerhoed, Brigitte Boeser-Nunnink, Silvia Broersen, and Hanneke Schuitemaker*

Department of Clinical Viro-Immunology, CLB, and Laboratory of Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Received 12 March 2001/Accepted 27 July 2001

In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4+ T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.

* Corresponding author. Mailing address: Dept. of Clinical Viro-Immunology, CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. Phone: 31-20-5123317. Fax: 31-20-5123310. E-mail: J_Schuitemaker{at}clb.nl.

Journal of Virology, November 2001, p. 10455-10459, Vol. 75, No. 21
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.21.10455-10459.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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