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Journal of Virology, January 2001, p. 750-758, Vol. 75, No. 2
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.2.750-758.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

Karen L. Mossman,1 Pascale F. Macgregor,2 Jacob J. Rozmus,1 Andrew B. Goryachev,3 Aled M. Edwards,2 and James R. Smiley1,*

Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2H71; Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada M5S 1A82; and Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada M5G 2M93

Received 23 August 2000/Accepted 25 October 2000

Virus infection induces an antiviral response that is predominantly associated with the synthesis and secretion of soluble interferon. Here, we report that herpes simplex virus type 1 virions induce an interferon-independent antiviral state in human embryonic lung cells that prevents plaquing of a variety of viruses. Microarray analysis of 19,000 human expressed sequence tags revealed induction of a limited set of host genes, the majority of which are also induced by interferon. Genes implicated in controlling the intracellular spread of virus and eliminating virally infected cells were among those induced. Induction of the cellular response occurred in the absence of de novo cellular protein synthesis and required viral penetration. In addition, this response was only seen when viral gene expression was inhibited, suggesting that a newly synthesized viral protein(s) may function as an inhibitor of this response.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, 1-41 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7. Phone: (780) 492-2308. Fax: (780) 492-7521. E-mail: jim.smiley{at}ualberta.ca.

Journal of Virology, January 2001, p. 750-758, Vol. 75, No. 2
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.2.750-758.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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