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Journal of Virology, January 2001, p. 1065-1071, Vol. 75, No. 2
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.2.1065-1071.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vivo Selection of T-Cell Receptor Junctional Region Sequences by HLA-A2 Human T-Cell Lymphotropic Virus Type 1 Tax11-19 Peptide Complexes

Mineki Saito,1 Graham P. Taylor,2 Akiko Saito,1 Yoshitaka Furukawa,3 Koichiro Usuku,4 Jonathan N. Weber,2 Mitsuhiro Osame,3 and Charles R. M. Bangham1,*

Departments of Immunology1 and Genito-Urinary Medicine and Communicable Diseases,2 Imperial College School of Medicine, St. Mary's Campus, London W2 1PG, United Kingdom, and Department of Medical Informatics4 and Third Department of Internal Medicine,3 Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

Received 15 June 2000/Accepted 13 October 2000

Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrophic virus type 1 Tax peptide-specific CD8+ T cells ex vivo. Antigen-specific amino acid motifs were identified in the T-cell receptor Vbeta CDR3 region of clonally expanded CD8+ T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vivo.

* Corresponding author. Mailing address: Department of Immunology, Imperial College School of Medicine, St. Mary's Campus, Norfolk Pl., London W2 1PG, United Kingdom. Phone: 44-20-7594-3730. Fax: 44-20-7402-0653. E-mail: c.bangham{at}ic.ac.uk.

Journal of Virology, January 2001, p. 1065-1071, Vol. 75, No. 2
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.2.1065-1071.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ozden, S., Cochet, M., Mikol, J., Teixeira, A., Gessain, A., Pique, C. (2004). Direct Evidence for a Chronic CD8+-T-Cell-Mediated Immune Reaction to Tax within the Muscle of a Human T-Cell Leukemia/Lymphoma Virus Type 1-Infected Patient with Sporadic Inclusion Body Myositis. J. Virol. 78: 10320-10327 [Abstract] [Full Text]  
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