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Journal of Virology, January 2001, p. 1044-1047, Vol. 75, No. 2
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.2.1044-1047.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The N-Terminal Region of the VP1 Protein of Swine Vesicular Disease Virus Contains a Neutralization Site That Arises upon Cell Attachment and Is Involved in Viral Entry

M. A. Jiménez-Clavero,1,* E. Escribano-Romero,1 A. J. Douglas,2 and V. Ley1

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain,1 and Department of Veterinary Science, Queens University, Belfast, Northern Ireland2

Received 22 May 2000/Accepted 20 October 2000

The N-terminal region of VP1 of swine vesicular disease virus (SVDV) is highly antigenic in swine, despite its internal location in the capsid. Here we show that antibodies to this region can block infection and that allowing the virus to attach to cells increases this blockage significantly. The results indicate that upon binding to the cell, SVDV capsid undergoes a conformational change that is temperature independent and that exposes the N terminus of VP1. This process makes this region accessible to antibodies which block virus entry.

* Corresponding author. Mailing address: INIA, Ctra. Coruña Km 7, 28040 Madrid, Spain. Phone: 34 91-3471497. Fax: 34 91-3572293. E-mail: majimene{at}inia.es.

Journal of Virology, January 2001, p. 1044-1047, Vol. 75, No. 2
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.2.1044-1047.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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