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Journal of Virology, September 2001, p. 8848-8853, Vol. 75, No. 18
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.18.8848-8853.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1

Fransje A. Koning,1 Dominique Schols,2 and Hanneke Schuitemaker1,*

Department of Clinical Viro Immunology, CLB-Sanquin, and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,1 and Laboratory of Virology and Chemotherapy, Rega Institute, Leuven, Belgium2

Received 15 August 2000/Accepted 1 June 2001

In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants.

* Corresponding author. Mailing address: Dept. of Clinical Viro Immunology, CLB-Sanquin, Plesmanlaan 125, P.O. Box 9190, 1066 CX Amsterdam, The Netherlands. Phone: 31-20-5123317. Fax: 31-20-5123310. E-mail: J_Schuitemaker{at}clb.nl.

Journal of Virology, September 2001, p. 8848-8853, Vol. 75, No. 18
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.18.8848-8853.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Bunnik, E. M., Quakkelaar, E. D., van Nuenen, A. C., Boeser-Nunnink, B., Schuitemaker, H. (2007). Increased Neutralization Sensitivity of Recently Emerged CXCR4-Using Human Immunodeficiency Virus Type 1 Strains Compared to Coexisting CCR5-Using Variants from the Same Patient. J. Virol. 81: 525-531 [Abstract] [Full Text]  
  • Stalmeijer, E. H. B., van Rij, R. P., Boeser-Nunnink, B., Visser, J. A., Naarding, M. A., Schols, D., Schuitemaker, H. (2004). In Vivo Evolution of X4 Human Immunodeficiency Virus Type 1 Variants in the Natural Course of Infection Coincides with Decreasing Sensitivity to CXCR4 Antagonists. J. Virol. 78: 2722-2728 [Abstract] [Full Text]  


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