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Journal of Virology, September 2001, p. 8348-8352, Vol. 75, No. 17
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.17.8348-8352.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Nuclear Export of Human Immunodeficiency Virus Type 1 Vpr Is Not Required for Virion Packaging

Yonchu Jenkins,1 Patricia V. Sanchez,1,2 Barbara E. Meyer,1 and Michael H. Malim1,3,*

Departments of Microbiology1 and Medicine3 and Cell and Molecular Biology Graduate Group,2 University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148

Received 18 December 2000/Accepted 30 May 2001

The human immunodeficiency virus type 1 Vpr protein is both packaged into virions and efficiently localized to the nucleus. In this report, we show that a significant fraction of Vpr also accumulates in the cytoplasm of virus-producing cells. Although Vpr shuttles between the nucleus and the cytoplasm, studies with an export-deficient Vpr mutant reveal that nuclear export is not required for virion incorporation.

* Corresponding author. Mailing address: Department of Microbiology, University of Pennsylvania School of Medicine, 347 B Clinical Research Bldg., 415 Curie Blvd., Philadelphia, PA 19104-6148. Phone: (215) 573-3493. Fax: (215) 573-2172. E-mail: malim{at}mail.med.upenn.edu.

Journal of Virology, September 2001, p. 8348-8352, Vol. 75, No. 17
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.17.8348-8352.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.