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Journal of Virology, August 2001, p. 7774-7777, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7774-7777.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Role for p53 in Gene Induction by Double-Stranded RNA

B. T. Hummer,1,2 X.-L. Li,1,2 and B. A. Hassel1,2,3,*

Greenebaum Cancer Center,1 Department of Microbiology and Immunology,2 and Molecular and Cell Biology Program,3 The University of Maryland, Baltimore, Maryland 21201

Received 2 October 2000/Accepted 22 May 2001

Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.

* Corresponding author. Mailing address: University of Maryland, Baltimore, Greenebaum Cancer Center, Bressler Research Building, 9th Floor, 655 W. Baltimore St., Baltimore, MD 21201. Phone: (410) 328-2344. Fax: (410) 328-6559. E-mail: bhassel{at}som.umaryland.edu.

Journal of Virology, August 2001, p. 7774-7777, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7774-7777.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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