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Journal of Virology, August 2001, p. 7744-7748, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7744-7748.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Analysis of Virus-Specific CD4+ T Cells during Long-Term Gammaherpesvirus Infection

Emilio Flaño,1,2 David L. Woodland,2 Marcia A. Blackman,2 and Peter C. Doherty1,*

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105,1 and Trudeau Institute, Saranac Lake, New York 129832

Received 1 February 2001/Accepted 24 May 2001

Major histocompatibility complex class II-mediated antigen presentation after intranasal infection with murine gammaherpesvirus 68 differs in mediastinal lymph nodes and spleen. Evidence that virus-specific CD4+ T cells were being stimulated was found as late as 6 to 8 months after infection, and cells specific for the viral gp15067-83 and ORF11168-180 peptides were maintained as a fairly stable proportion of the total response.

* Corresponding author. Mailing address: Department of Immunology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105. Phone: (901) 495-3470. Fax: (901) 495-3107. E-mail: peter.doherty{at}stjude.org.

Journal of Virology, August 2001, p. 7744-7748, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7744-7748.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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