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Journal of Virology, August 2001, p. 7629-7636, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7629-7636.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The Ribosome Binding Site of Hepatitis C Virus mRNA

J. Robin Lytle, Lily Wu, and Hugh D. Robertson*

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021

Received 12 February 2001/Accepted 17 May 2001

Hepatitis C virus (HCV) infects an estimated 170 million people worldwide, the majority of whom develop a chronic infection which can lead to severe liver disease, and for which no generally effective treatment yet exists. A promising target for treatment is the internal ribosome entry site (IRES) of HCV, a highly conserved domain within a highly variable RNA. Never before have the ribosome binding sites of any IRES domains, cellular or viral, been directly characterized. Here, we reveal that the HCV IRES sequences most closely associated with 80S ribosomes during protein synthesis initiation are a series of discontinuous domains together comprising by far the largest ribosome binding site yet discovered.

* Corresponding author. Mailing address: Room E-013, Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Ave., New York, NY 10021. Phone: (212) 746-6400. Fax: (212) 746-8144. E-mail: hdrober{at}mail.med.cornell.edu.

Journal of Virology, August 2001, p. 7629-7636, Vol. 75, No. 16
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.16.7629-7636.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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