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Journal of Virology, July 2001, p. 6705-6709, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6705-6709.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity

Ali M. Harandi,1 Bo Svennerholm,2 Jan Holmgren,1 and Kristina Eriksson1,*

Departments of Medical Microbiology and Immunology1 and Clinical Virology,2 Göteborg University, 413 46 Göteborg, Sweden

Received 8 January 2001/Accepted 25 April 2001

Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a protective gamma interferon-mediated immune response.

* Corresponding author. Mailing address: Department of Medical Microbiology & Immunology, Guldhedsgatan 10A, 413 46 Göteborg, Sweden. Phone: (46) 31-3424761. Fax: (46) 31-820160. E-mail: kristina.eriksson{at}microbio.gu.se.

Journal of Virology, July 2001, p. 6705-6709, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6705-6709.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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