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Journal of Virology, July 2001, p. 6687-6691, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6687-6691.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Pathogenesis of Influenza A (H5N1) Virus Infection in a Primate Model

G. F. Rimmelzwaan,1 T. Kuiken,1 G. van Amerongen,2 T. M. Bestebroer,1 R. A. M. Fouchier,1 and A. D. M. E. Osterhaus1,*

Institute of Virology, National Influenza Center, Erasmus Medical Center Rotterdam, Rotterdam,1 and Central Animal Laboratory, National Institute of Public Health and the Environment, Bilthoven,2 The Netherlands

Received 31 January 2001/Accepted 13 April 2001

Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

* Corresponding author. Mailing address: Institute of Virology, National Influenza Center, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31 10 408 8066. Fax: 31 10 408 9485. E-mail: osterhaus{at}viro.fgg.eur.nl.

Journal of Virology, July 2001, p. 6687-6691, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6687-6691.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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