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Journal of Virology, July 2001, p. 6566-6571, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6566-6571.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Genetic Diversity in RNA Virus Quasispecies Is Controlled by Host-Virus Interactions

William L. Schneider and Marilyn J. Roossinck*

Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73402

Received 26 February 2001/Accepted 16 April 2001

Many RNA viruses have genetically diverse populations known as quasispecies. Important biological characteristics may be related to the levels of diversity in the quasispecies (quasispecies cloud size), including adaptability and host range. Previous work using Tobacco mosaic virus and Cucumber mosaic virus indicated that evolutionarily related viruses have very different levels of diversity in a common host. The quasispecies cloud size for these viruses remained constant throughout serial passages. Inoculation of these viruses on a number of hosts demonstrated that quasispecies cloud size is not constant for these viruses but appears to be dependent on the host. The quasispecies cloud size remained constant as long as the viruses were maintained on a given host. Shifting the virus between hosts resulted in a change in cloud size to levels associated with the new host. Quasispecies cloud size for these viruses is related to host-virus interactions, and understanding these interactions may facilitate the prediction and prevention of emerging viral diseases.

* Corresponding author. Mailing address: Plant Biology Division, Samuel Roberts Noble Foundation, P.O. Box 2180, Ardmore, OK 73402. Phone: (580) 221-7342. Fax: (580) 221-7380. E-mail: mroossinck{at}noble.org.

Journal of Virology, July 2001, p. 6566-6571, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6566-6571.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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