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Journal of Virology, July 2001, p. 6384-6391, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6384-6391.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Target Cell Populations of Human Immunodeficiency Virus Type 1 in Peripheral Blood Lymphocytes with Different Chemokine Receptors at Various Stages of Disease Progression

Prasert Auewarakul,1,* Kantima Sangsiriwut,2 Surapol Suwanagool,2 and Chantapong Wasi1

Department of Microbiology1 and Department of Preventive and Social Medicine,2 Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Received 15 August 2000/Accepted 13 April 2001

We studied the distribution of human immunodeficiency virus type 1 (HIV-1) DNA in CCR5-positive and -negative peripheral blood lymphocyte populations in HIV-1-infected individuals. While HIV-1 DNA in the CCR5-positive population showed no correlation with CD4 count, the increase of total HIV-1 DNA with lower CD4 count was mainly contributed by the increase of HIV-1 DNA in the CCR5-negative population. This might indicate the change in coreceptor usage from CCR5 to CXCR4 in later stages of disease progression. However, some of the samples with a high viral DNA load in the CCR5-negative population did not have any characteristic of the V3 loop sequence that is compatible with CXCR4 usage or the syncytium-inducing (SI) phenotype. We also did not find any known characteristic change predictive of the SI phenotype in V1 and V2 sequences. Our findings showed that there might be a shift in target cell populations during disease progression, and this shift was not necessarily associated with the genetic changes characteristic of CXCR4 usage.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine Siriraj Hospital, Bangkok 10700, Thailand. Phone: 662-4197068-9. Fax: 662-4184148. E-mail: sipaw{at}mahidol.ac.th.

Journal of Virology, July 2001, p. 6384-6391, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6384-6391.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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