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Journal of Virology, July 2001, p. 6348-6358, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6348-6358.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Evidence for Retroviral Intramolecular Recombinations

Jiayou Zhang* and Yan Ma

Department of Microbiology and Immunology and Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536-0096

Received 1 March 2000/Accepted 14 April 2001

As a consequence of being diploid, retroviruses have a high recombination rate. Naturally occurring retroviruses contain two repeat sequences (R regions) flanking either end of their RNA genomes, and recombination between these two R regions occurs at a high rate. We deduced that recombination may occur between two sequences within the same RNA molecule (intramolecular) as well as between sequences present within two separate RNA molecules (intermolecular). Intramolecular recombination would usually result in a deletion within the progeny provirus. In this report, we demonstrate that intramolecular recombination between two identical sequences occurred within a chimeric RNA vector. In addition, high rates of recombination between two identical sequences within the same RNA molecule resulted mostly from intramolecular recombination.

* Corresponding author. Mailing address: Combs Research Bldg., Room 206, University of Kentucky, 800 Rose St., Lexington, KY 40536-0096. Phone: (859) 257-4456. Fax: (859) 257-8940. E-mail: jzhan1{at}pop.uky.edu.

Journal of Virology, July 2001, p. 6348-6358, Vol. 75, No. 14
0022-538X/01/$04.00+0   DOI: 10.1128/JVI.75.14.6348-6358.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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